Canada ratified the WHO Framework Convention on Tobacco Control (FCTC) on November 26, 2004. In 2002, a team of researchers from Australia, Canada, the United Kingdom, and the United States launched the flagship ITC Four Country (4C) Survey. Nine survey waves of ITC 4C Survey have been conducted among a cohort of adult smokers aged 18 and older in Canada. In 2016, the team expanded the cigarette smoking 4C survey into the ITC Four Country Smoking and Vaping (4CV3) Survey, to investigate the relationship between nicotine vaping products (NVPs) and/or heated tobacco products (HTPs) and cigarette use, and to inform emerging policies related to NVPs and/or HTPs. Three survey waves of the 4CV Survey have been conducted among adult smokers, recent former smokers, vapers, and HTP users in Canada as well as Australia, England, and the United States. These four countries have similar cigarette-smoking rates, but divergent policies on vaping product and/or HTP use. The ITC Project in collaboration with researchers at Roswell Park Comprehensive Cancer Center conducted in 2018, the ITC Japan-Canada Heated Tobacco Products (JCH) Survey. Fieldwork in Canada consisted of both a survey and a urine collection component in the two countries. In both surveys, tobacco users and non-users are adults aged 18 and older.