Scientific Journal Articles
Showing 501-525 of 769 Results
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Thompson, et al. 2014. Accounting for the effects of data collection method: Application to the International Tobacco Control Netherlands Survey [show abstract ▼] [hide abstract ▲] [access full article]
Citation
Thompson, M.E., Huang, C., Boudreau, C., Fong, G.T., van den Putte, B., Nagelhout, G.E., Willemsen, M.C. (2014). Accounting for the effects of data collection method: Application to the International Tobacco Control Netherlands Survey. Population, 68(3), 447-471.
Abstract
Qualitative surveys employ an ever wider range of data collection methods. The development of telephone surveys in the 1900s offered a cheaper alternative to face-to-face interviews (Riandey and Firdion, 1993). Later, as the number of cell phone owners increased, technical advances made it possible to conduct detailed interviews and to directly select random samples of adults by means of cell phone numbers. More recently, the spread of the Internet has made it possible to conduct surveys with minimal data collection costs on “spontaneous” samples of volunteers or on representative samples of respondents recruited by phone. These innovations raise questions of sample representativeness and of the effect of data collection mode on the responses obtained. Analysing the Dutch version of an international survey on tobacco control, Mary Thompson and her colleagues compare the results obtained on two subsamples, on that responded via the web, and the other by phone. They highlight differences linked to the respondents' characteristics and other attributable to the data collection mode, and present a method or estimating the results that would have been obtained using a single collection method, i.e. that used in the other countries.
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Caruso, et al. 2013. Toxic metal concentrations in cigarettes obtained from U.S. smokers in 2009: Results from the International Tobacco Control (ITC) United States Survey Cohort [show abstract ▼] [hide abstract ▲] [access full article]
Citation
Caruso, R., O’Connor, R.J., Stephens, W.E., Cummings, K.M., Fong, G.T. (2013). Toxic metal concentrations in cigarettes obtained from U.S. smokers in 2009: Results from the International Tobacco Control (ITC) United States Survey Cohort. International Journal of Environmental Research and Public Health, 11(1), 202-217.
Abstract
Smoking-related diseases can be attributed to the inhalation of many different toxins, including heavy metals, which have a host of detrimental health effects. The current study reports the levels of arsenic (As), cadmium (Cd), chromium (Cr), nickel (Ni), and lead (Pb) in cigarettes obtained from adult smokers participating in the 2009 wave of the ITC United States Survey (N = 320). The mean As, Cd, Cr, Ni, and Pb levels were 0.17, 0.86, 2.35, 2.21, and 0.44 μg/g, respectively. There were some differences in metal concentrations of cigarette brands produced by different manufacturers, suggesting differences in the source of tobaccos used by different companies. For Ni, there were significant pairwise differences between Philip Morris U.S. (PMUSA) and R.J. Reynolds (RJR) brands (PMUSA higher; p < 0.001), PMUSA and other manufacturer (OM) brands (PMUSA higher; p < 0.001), and RJR and OM brands (RJR higher; p = 0.006). For Cr, RJR brands had higher levels than did OM brands (p = 0.02). Levels of As, Cd, and Pb did not differ significantly across manufacturer groups (p > 0.10). Because of the variety of toxic heavy metals in cigarette tobacco, and their numerous negative health effects, metal content in cigarette tobacco should be reduced.
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Hitchman, et al. 2013. Changes in effectiveness of cigarette health warnings over time in Canada and the United States, 2002-2011 [show abstract ▼] [hide abstract ▲] [access full article]
Citation
Hitchman, S.C., Driezen, P., Logel, C., Hammond, D., Fong, G.T. (2014). Changes in effectiveness of cigarette health warnings over time in Canada and the United States, 2002 - 2011. Nicotine & Tobacco Research, 16(5), 536-543.
Abstract
Introduction: Article 11 of the World Health Organization's Framework Convention on Tobacco Control (FCTC) requires countries to implement health warnings on tobacco products. The Article 11 Guidelines advise countries to periodically rotate warnings to prevent “wearout” of the health warnings. This study investigates potential wearout of cigarette health warnings over a period of 9 years in 2 countries: Canada, where larger pictorial warnings were implemented approximately 1 year prior to the study, and in the United States, where small text-only warnings were in place for 17 years at the beginning of the study.
Methods: Data were drawn from national samples of smokers from the International Tobacco Control (ITC) Surveys in Canada (N = 5,309), and the United States (N = 6,412) recruited originally by telephone using random digit dialing. Changes in 4 measures of health warning effectiveness and in a composite Labels Impact Index were examined over 8 waves of survey data (2002-2011). Analyses were conducted in 2012.
Results: The health warning effectiveness measures and the Labels Impact Index indicated that the effectiveness of both the Canadian, and the U.S. warnings declined significantly over time. The Canadian warnings showed greater declines in effectiveness than the U.S. warnings, likely due to the initial novelty of the Canadian warnings. Despite the greater decline in Canada, the Canadian pictorial warnings were significantly more effective than the U.S. text-only warnings throughout the study.
Conclusions: Health warnings decline in effectiveness over time. Health warnings on tobacco products should be changed periodically to maintain effectiveness.
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Thrasher, et al. 2013. Tobacco smoke exposure in public places and workplaces after smoke-free policy implementation: A longitudinal analysis of smoker cohorts in Mexico and Uruguay [show abstract ▼] [hide abstract ▲] [access full article]
Citation
Thrasher, J.F., Naveli Abad-Vivero, E., Sebrie, E.M., Barrientos-Gutierrez, I., Boado Martinez, M., Yong, H.H., Arillo-Santillán, E., Bianco, E. (2013). Tobacco smoke exposure in public places and workplaces after smoke-free policy implementation: A longitudinal analysis of smoker cohorts in Mexico and Uruguay. Health & Policy Planning, 28(8), 789-798.
Abstract
Objective: To determine the prevalence, correlates and changes in secondhand smoke (SHS) exposure over the period after comprehensive smoke-free policy implementation in two Latin American countries.
Methods: Data were analysed from population-based representative samples of adult smokers and recent quitters from the 2008 and 2010 waves of the International Tobacco Control Policy Evaluation Survey in Mexico (n = 1766 and 1840, respectively) and Uruguay (n = 1379 and 1411, respectively). Prevalence of SHS exposure was estimated for regulated venues, and generalized estimating equations were used to determine correlates of SHS exposure.
Results: Workplace SHS exposure in the last month was similar within and across countries (range: Mexico 20–25%; Uruguay 14–29%). At the most recent restaurant visit, SHS exposure was lower where comprehensive smoke-free policies were implemented (range: Uruguay 6–9%; Mexico City 5–7%) compared with Mexican cities with weaker policies, where exposure remained higher but decreased over time (32–17%). At the most recent bar visit, SHS exposure was common (range: Uruguay 8–36%; Mexico City 23–31%), although highest in jurisdictions with weaker policies (range in other Mexican cities: 74–86%). In Uruguay, males were more likely than females to be exposed to SHS across venues, as were younger compared with older smokers in Mexico.
Conclusions: Comprehensive smoke-free policies are more effective than weaker policies, although compliance in Mexico and Uruguay is not as high as desired.
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Li, et al. 2013. Impact of point-of-sale tobacco display bans: Findings from the International Tobacco Control Four Country Survey [show abstract ▼] [hide abstract ▲] [access full article]
Citation
Li, L., Borland, R., Fong, G.T., Thrasher, J.F., Hammond, D., Cummings, K.M. (2013). Impact of point-of-sale tobacco display bans: Findings from the International Tobacco Control Four Country Survey. Health Education Research, 28(5), 898-910.
Abstract
This study examined the impact of point-of-sale (POS) tobacco marketing restrictions in Australia and Canada, in relation to the United Kingdom and the United States where there were no such restrictions during the study period (2006–10). The data came from the International Tobacco Control Four Country Survey, a prospective multi-country cohort survey of adult smokers. In jurisdictions where POS display bans were implemented, smokers’ reported exposure to tobacco marketing declined markedly. From 2006 to 2010, in Canada, the percentages noticing POS tobacco displays declined from 74.1 to 6.1% [adjusted odds ratio (OR)¼0.26, P<0.001]; and reported exposure to POS tobacco advertising decreased from 40.3 to 14.1% (adjusted OR¼0.61, P<0.001). Similarly, in Australia, noticing of POS displays decreased from 73.9 to 42.9%. In contrast, exposure to POS marketing in the United States and United Kingdom remained high during this period. In parallel, there were declines in reported exposures to other forms of advertising/promotion in Canada and Australia, but again, not in the United States or United Kingdom. Impulse purchasing of cigarettes was lower in places that enacted POS display bans. These findings indicate that implementing POS tobacco display bans does result in lower exposure to tobacco marketing and less frequent impulse purchasing of cigarettes.
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Nargis, et al. 2013. The choice of discount brand cigarettes: A comparative analysis of International Tobacco Control Surveys in Canada and the USA (2002-2005) [show abstract ▼] [hide abstract ▲] [access full article]
Citation
Nargis, N., Fong, G.T., Chaloupka, F., Li, Q. (2014). The choice of discount brand cigarettes: A comparative analysis of International Tobacco Control Surveys in Canada and the United States (2002-05). Tobacco Control, 23(Suppl 1), i86-i96.
Abstract
Background: Increasing tobacco taxes to increase price is a proven tobacco control measure. This article investigates how smokers respond to tax and price increases in their choice of discount brand cigarettes versus premium brands.
Objective: To estimate how increase in the tax rate can affect smokers' choice of discount brands versus premium brands.
Methods: Using data from International Tobacco Control surveys in Canada and the USA, a logit model was constructed to estimate the probability of choosing discount brand cigarettes in response to its price changes relative to premium brands, controlling for individual-specific demographic and socioeconomic characteristics and regional effects. The self-reported price of an individual smoker is used in a random-effects regression model to impute price and to construct the price ratio for discount and premium brands for each smoker, which is used in the logit model.
Findings: An increase in the ratio of price of discount brand cigarettes to the price of premium brands by 0.1 is associated with a decrease in the probability of choosing discount brands by 0.08 in Canada. No significant effect is observed in case of the USA.
Conclusions: The results of the model explain two phenomena: (1) the widened price differential between premium and discount brand cigarettes contributed to the increased share of discount brand cigarettes in Canada in contrast to a relatively steady share in the USA during 2002-2005 and (2) increasing the price ratio of discount brands to premium brands-which occurs with an increase in specific excise tax-may lead to upward shifting from discount to premium brands rather than to downward shifting. These results underscore the significance of studying the effectiveness of tax increases in reducing overall tobacco consumption, particularly for specific excise taxes.
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Fong, et al. 2013. Evaluating the effectiveness of France's indoor smoke-free law 1 year and 5 years after implementation: Findings from the ITC France survey [show abstract ▼] [hide abstract ▲] [access full article]
Citation
Fong, G.T., Craig, L., Guignard, R., Nagelhout, G.E., Tait, M., Driezen, P., Kennedy, R.D., Boudreau, C., Wilquin, J.L., Deutsch, A., Beck, F. (2013). Evaluating the effectiveness of France's indoor smoke-free law 1 year and 5 years after implementation: Findings from the ITC France Survey. PLOS One, 8(6), 66692.
Abstract
France implemented a comprehensive smoke-free law in two phases: Phase 1 (February 2007) banned smoking in workplaces, shopping centres, airports, train stations, hospitals, and schools; Phase 2 (January 2008) banned smoking in hospitality venues (bars, restaurants, hotels, casinos, nightclubs). This paper evaluates France’s smoke-free law based on the International Tobacco Control Policy Evaluation Project in France (the ITC France Project), which conducted a cohort survey of approximately 1,500 smokers and 500 non-smokers before the implementation of the laws (Wave 1) and two waves after the implementation (Waves 2 and 3). Results show that the smoke-free law led to a very significant and near-total elimination of observed smoking in key venues such as bars (from 94–97% to 4%) and restaurants (from 60–71% to 2–3%) at Wave 2, which was sustained four years later (6–8% in bars; 1–2% in restaurants). The reduction in self-reported smoking by smoking respondents was nearly identical to the effects shown in observed smoking. Observed smoking in workplaces declined significantly after the law (from 41–48% to 18–20%), which continued to decline at Wave 3 (to 14–15%). Support for the smoke-free laws increased significantly after their implementation and continued to increase at Wave 3 (p,.001 among smokers for bars and restaurants; p,.001 among smokers and p = .003 for non-smokers for workplaces). The findings demonstrate that smoke-free policies that are implemented in ways consistent with the Guidelines for Article 8 of the WHO Framework Convention on Tobacco Control (WHO FCTC) lead to substantial and sustained reductions in indoor smoking while also leading to high levels of support by the public. Moreover, contrary to arguments by opponents of smoke-free laws, smoking in the home did not increase after the law was implemented and prevalence of smoke-free homes among smokers increased from 23.2% before the law to 37.2% 5 years after the law.
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Sirirassamee , et al. 2013. Trends in tobacco use among Thai adolescents [show abstract ▼] [hide abstract ▲] [access full article]
Citation
Sirirassamee, T., Sirirassamee, B. (2013). Trends in tobacco use among Thai adolescents. Journal of the Medical Association of Thailand, 96(1), 78-84.
Abstract
Background: Tobacco use continues to be the leading global cause of preventable death. Understanding the trends in prevalence of cigarette smoking and smoking behaviors among adolescents enables physicians to target prevention resources more effectively.
Objective: The objectives of this study were to monitor the prevalence of smoking, to compare the prevalence of smoking in subgroups of region, gender and age, and to explore smoking behavior among adolescent smokers.
Material and Method: The International Tobacco Control Survey-Thailand is a population-based, national representative, longitudinal survey conducted among adolescents between the ages of 13-17. Adolescents were sampled from Bangkok and 4 regions of Thailand using stratified multistage sampling. Three surveys were conducted during January 2005 to March 2008. Respondents were asked to complete self-administered questionnaires. Data was analyzed using descriptive statistics.
Results: Overall, smoking prevalence has increased from 12.0% in wave 1 to 14.3% in wave 2 and 18.3% in wave 3. Smoking prevalence in males was more than 10 times higher than females. Manufactured cigarettes were most frequently used by adolescents. More than 70% of smokers reported that they smoked manufactured cigarettes. Total amount of tobacco use per day increased from wave 1 to wave 3. The proportion of smokers who reported that they bought cigarettes by themselves increased during the follow-up waves (38.3%, 60.9%, 68.2% respectively). More than 20% of smokers reported that they never plan to quit smoking.
Conclusion: Smoking prevalence among thai adolescents was apparently increased.
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Nagelhout, et al. 2013. Socioeconomic and country variations in cross-border cigarette purchasing as tobacco tax avoidance strategy. Findings from the ITC Europe Surveys [show abstract ▼] [hide abstract ▲]
Citation
Nagelhout, G.E., van den Putte, B., Allwright, S., Mons, U., McNeill, A., Guignard, R., Beck, F., Siahpush, M., Joossens, L., Fong, G.T., de Vries, H., Willemsen, M.C. (2014). Socioeconomic and country variations in cross-border cigarette purchasing as tobacco tax avoidance strategy: Findings from the ITC Europe Surveys. Tobacco Control, 23(Suppl 1), i30-i38.
Abstract
Background: Legal tobacco tax avoidance strategies such as cross-border cigarette purchasing may attenuate the impact of tax increases on tobacco consumption. Little is known about socioeconomic and country variations in cross-border purchasing.
Objective: To describe socioeconomic and country variations in cross-border cigarette purchasing in six European countries.
Methods: Cross-sectional data from adult smokers (n=7873) from the International Tobacco Control (ITC) Surveys in France (2006/2007), Germany (2007), Ireland (2006), The Netherlands (2008), Scotland (2006) and the rest of the UK (2007/2008) were used. Respondents were asked whether they had bought cigarettes outside their country in the last 6 months and how often.
Findings: In French and German provinces/states bordering countries with lower cigarette prices, 24% and 13% of smokers, respectively, reported purchasing cigarettes frequently outside their country. In non-border regions of France and Germany, and in Ireland, Scotland, the rest of the UK and The Netherlands, frequent purchasing of cigarettes outside the country was reported by 2-7% of smokers. Smokers with higher levels of education or income, younger smokers, daily smokers, heavier smokers and smokers not planning to quit smoking were more likely to purchase cigarettes outside their country.
Conclusions: Cross-border cigarette purchasing is more common in European regions bordering countries with lower cigarette prices and is more often reported by smokers with higher education and income. Increasing taxes in countries with lower cigarette prices, and reducing the number of cigarettes that can be legally imported across borders could help to avoid cross-border purchasing.
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Partos, et al. 2013. Cigarette packet warning labels can prevent relapse: Findings from the International Tobacco Control 4-Country Policy Evaluation Cohort Study [show abstract ▼] [hide abstract ▲] [access full article]
Citation
Partos, T.R., Borland, R., Yong, H.H., Thrasher, J.F., Hammond, D. (2013). Cigarette packet warning labels can prevent relapse: Findings from the International Tobacco Control 4-Country Policy Evaluation Cohort Study. Tobacco Control, 22(1), 43-50.
Abstract
Objectives: To investigate the links between health warning labels (WLs) on cigarette packets and relapse among recently quit smokers.
Design: Prospective longitudinal cohort survey.
Setting: Australia, Canada, the UK and the USA.
Participants: 1936 recent ex-smokers (44.4% male) from one of the first six waves (2002–2007) of the International Tobacco Control 4-Country policy evaluation survey, who were followed up in the next wave.
Main outcome measures: Whether participants had relapsed at follow-up (approximately 1 year later).
Results: In multivariate analysis, very frequent noticing of WLs among ex-smokers was associated with greater relapse 1 year later (OR: 1.52, 95% CI 1.11 to 2.09, p<0.01), but this effect disappeared after controlling for urges to smoke and self-efficacy (OR: 1.29, 95% CI 0.92 to 1.80, p=0.135). In contrast, reporting that WLs make staying quit ‘a lot’ more likely (compared with ‘not at all’ likely) was associated with a lower likelihood of relapse 1 year later (OR: 0.65, 95% CI 0.49 to 0.86, p<0.01) and this effect remained robust across all models tested, increasing in some.
Conclusions: This study provides the first longitudinal evidence that health warnings can help ex-smokers stay quit. Once the authors control for greater exposure to cigarettes, which is understandably predictive of relapse, WL effects are positive. However, it may be that ex-smokers need to actively use the health consequences that WLs highlight to remind them of their reasons for quitting, rather than it being something that happens automatically. Ex-smokers should be encouraged to use pack warnings to counter urges to resume smoking. Novel warnings may be more likely to facilitate this.
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Cooper, et al. 2013. Variations in daily cigarette consumption on work days compared with nonwork days and associations with quitting: Findings from the International Tobacco Control Four-Country Survey [show abstract ▼] [hide abstract ▲]
Citation
Cooper, J., Borland, R., Yong, H.H., Hyland, A., Cummings, K.M. (2013). Variations in daily cigarette consumption on work days compared with nonwork days and associations with quitting: Findings from the International Tobacco Control Four-Country Survey. Nicotine & Tobacco Research, 15(1), 192-198.
Abstract
Introduction: We explore whether reported daily cigarette consumption differs between work days and nonwork days and whether variation in consumption between work days and nonwork days influences quitting and abstinence from smoking. We also explore whether effects are independent of measures of addiction and smoking restrictions at work and home.
Methods: Data were from 5,732 respondents from the first five waves of the International Tobacco Control FourCountry Survey, occurring between 2002 and 2006. Respondents were current smokers employed outside the home. Variation in daily cigarette consumption on work days compared with nonwork days at one wave was used to predict the likelihood of making an attempt and the likelihood of maintaining a quit attempt for at least a month at the next wave. Generalized estimating equations were used to combine data for multiple waves.
Results: Just under half reported smoking more on a nonwork day, a little over a third reported no difference, and around one fifth reported smoking more on a work day. Controlling for possible confounding factors, smoking more on a work day was associated with making quit attempts. Among people who made a quit attempt, variation in consumption did not consistently predict one month's abstinence, being positive in Australia, but negative in the United Kingdom.
Conclusion: Those who smoke more on work days try to quit more. Country differences for success may be related to the extent of bans on smoking, with those smoking more on work days more likely to succeed where bans in workplaces and public places were more prevalent, such as Australia at the time.
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Zawahir, et al. 2013. Effectiveness of antismoking media messages and education among adolescents in Malaysia and Thailand: Findings from the International Tobacco Control Southeast Asia Project [show abstract ▼] [hide abstract ▲]
Citation
Zawahir, S., Omar, M., Awang, R., Yong, H.H., Borland, R., Sirirassamee, B., Fong, G.T., Hammond, D. (2013). Effectiveness of antismoking media messages and education among adolescents in Malaysia and Thailand: Findings from the International Tobacco Control Southeast Asia (ITC-SEA) Project. Nicotine & Tobacco Research, 15(2), 482-491.
Abstract
Introduction: Finding ways to discourage adolescents from taking up smoking is important because those who begin smoking at an earlier age are more likely to become addicted and have greater difficulty in quitting. This article examined whether anti smoking messages and education could help to reduce smoking susceptibility among adolescents in two Southeast Asian countries and to explore the possible moderating effect of country and gender.
Methods: Data came from Wave 1 of the International Tobacco Control Southeast Asia Project (ITC-SEA) survey conducted in Malaysia (n = 1,008) and Thailand (n = 1,000) where adolescents were asked about receiving antismoking advice from nurses or doctors, being taught at schools about the danger of smoking, noticing antismoking messages, knowledge of health effects of smoking, beliefs about the health risks of smoking, smoking susceptibility, and demographic information. Data were analyzed using chi-square tests and logistic regression models.
Results: Overall, significantly more Thai adolescents reported receiving advice from their nurses or doctors about the danger of smoking (p < .001), but no country difference was observed for reported antismoking education in schools and exposure to antismoking messages. Multivariate analyses revealed that only provision of antismoking education at schools was significantly associated with reduced susceptibility to smoking among female Malaysian adolescents (OR = 0.26). Higher knowledge of smoking harm and higher perceived health risk of smoking were associated with reduced smoking susceptibility among Thai female (OR = 0.52) and Malaysian male adolescents (OR = 0.63), respectively.
Conclusions: Educating adolescents about the dangers of smoking in schools appears to be the most effective means of reducing adolescents’ smoking susceptibility in both countries, although different prevention strategies may be necessary to ensure effectiveness for male and female adolescents.
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Kasza, et al. 2013. Effectiveness of stop-smoking medications: Findings from the International Tobacco Control (ITC) Four Country Survey [show abstract ▼] [hide abstract ▲]
Citation
Kasza, K.A., Hyland, A., Borland, R., McNeill, A., Bansal-Travers, M., Fix, B.V., Hammond, D., Fong, G.T., Cummings, K.M. (2013). Effectiveness of stop-smoking medications: Findings from the International Tobacco Control (ITC) Four Country Survey. Addiction, 108(1), 193-202.
Abstract
Aim: To evaluate the population effectiveness of stop-smoking medications while accounting for potential recall bias by controlling for quit attempt recency.
Design: Prospective cohort survey.
Setting: United Kingdom, Canada, Australia and the United States.
Participants: A total of 7436 adult smokers (18+ years) selected via random digit dialling and interviewed as part of the International Tobacco Control Four Country Survey (ITC-4) between 2002 and 2009. Primary analyses utilized the subset of respondents who participated in 2006 or later (n = 2550).
Measurements: Continuous abstinence from smoking for 1 month/6 months.
Findings: Among participants who recalled making a quit attempt within 1 month of interview, those who reported using varenicline, bupropion or nicotine patch were more likely to maintain 6-month continuous abstinence from smoking compared to those who attempted to quit without medication [adjusted odds ratio (OR) 5.84, 95% confidence interval (CI) (2.12–16.12), 3.94 (0.87–17.80), 4.09 (1.72–9.74), respectively]; there were no clear effects for oral NRT use. Those who did not use any medication when attempting to quit tended to be younger, to be racial/ethnic minorities, to have lower incomes and to believe that medications do not make quitting easier.
Conclusions: Consistent with evidence from randomized controlled trials, smokers in the United Kingdom, Canada, Australia and the United States are more likely to succeed in quit attempts if they use varenicline, bupropion or nicotine patch. Previous population studies that failed to find an effect failed to control adequately for important sources of bias.
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McKee, et al. 2013. Longitudinal associations between smoking cessation medications and alcohol consumption among smokers in the International Tobacco Control Four Country Survey [show abstract ▼] [hide abstract ▲] [access full article]
Citation
McKee, S., Young-Wolff, K.C., Harrison, E.L., Cummings, K.M., Borland, R., Kahler, C.W., Fong, G.T., Hyland, A. (2013). Longitudinal associations between smoking cessation medications and alcohol consumption among smokers in the International Tobacco Control Four Country Survey. Alcoholism Clinical and Experimental Research, 37(5), 804-810.
Abstract
Background: Available evidence suggests that quitting smoking does not alter alcohol consumption. However, smoking cessation medications may have a direct impact on alcohol consumption independent of any effects on smoking cessation. Using an international longitudinal epidemiological sample of smokers, we evaluated whether smoking cessation medications altered alcohol consumption independent of quitting smoking.
Methods: Longitudinal data were analyzed from the International Tobacco Control Four Country (ITC-4) Survey between 2007 and 2008, a telephone survey of nationally representative samples of smokers from the United Kingdom, Australia, Canada, and the United States (n = 4,995). Quantity and frequency of alcohol consumption, use of smoking cessation medications (varenicline, nicotine replacement [NRT], and no medications), and smoking behavior were assessed across 2 yearly waves. Controlling for baseline drinking and changes in smoking status, we evaluated whether smoking cessation medications were associated with reduced alcohol consumption.
Results: Varenicline was associated with a reduced likelihood of any drinking compared with nicotine replacement (OR = 0.56; 95% CI = 0.34 to 0.94), and consuming alcohol once a month or more compared to nicotine replacement (OR = 0.43; 95% CI = 0.27 to 0.69) or no medication (OR = 0.63; 95% CI = 0.41 to 0.99). Nicotine replacement was associated with an increased likelihood of consuming alcohol once a month or more compared to no medication (OR = 1.14; 95% CI = 1.03 to 1.25). Smoking cessation medications were not associated with more frequent drinking (once a week or more) or typical quantity consumed per episode. Medication effects on drinking frequency were independent of smoking cessation.
Conclusions: This epidemiological investigation demonstrated that varenicline was associated with a reduced frequency of alcohol consumption. Continued work should clarify under what conditions nicotine replacement therapies may increase or decrease patterns of alcohol consumption.
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Swayampakala, et al. 2013. Level of cigarette consumption and quit behaviour in a population of low-intensity smokers: Longitudinal results from the International Tobacco Control (ITC) Survey in Mexico [show abstract ▼] [hide abstract ▲]
Citation
Swayampakala, K., Thrasher, J.F., Carpenter, M.J., Reynales-Shigematsu, L.M., Cupertino, P., Berg, C. (2013). Level of cigarette consumption and quit behavior in a population of low-intensity smokers: Longitudinal results from the International Tobacco Control (ITC) Survey in Mexico. Addictive Behaviours, 38(14), 1958-1965.
Abstract
Background: Mexican smokers are more likely to be non-daily smokers and to consume fewer cigarettes per day than smokers in other countries. Little is known about their quit behaviors.
Aim: The aim of this study is to determine factors associated with having made a quit attempt and being successfully quit at 14-month follow-up in a population-based cohort of adult Mexicans who smoke at different levels of intensity.
Design: A longitudinal analysis of wave-III and wave-IV (2010) Mexican administration of International Tobacco Control Policy Evaluation Project was conducted.
Setting: This study was conducted in six large urban centers in Mexico Participants: The participants of this study comprised 1206 adults who were current smokers at wave-III and who were followed to wave-IV.
Measurements: We compared three groups of smokers: non-daily smokers—who did not smoke every day in the past 30 days (n=398), daily light smokers who smoked every day at a rate of ≤5 cigarettes per day (n=368) and daily heavy smokers who smoked every day at a rate of >5 cigarettes per day (n=434). Data on smoking behavior, psychosocial characteristics and socio-demographics were collected at baseline and after 14 months.
Findings: In multivariate logistic regression predicting having made a quit attempt at follow-up, significant factors included being a non-daily smoker versus a heavy daily smoker (ORadj=1.83, 95% CI: 1.19–2.83), less perceived addiction (ORadj=1.86, 95% CI: 1.20–2.87), greater worry that cigarettes will damage health (ORadj=2.04, 95% CI: 1.16–3.61) and having made a quit attempt in the past year at baseline (ORadj=1.70, 95% CI: 1.23–2.36). In multivariate logistic regression predicting being successfully quit at one-year follow-up, significant factors included being a non-daily smoker versus a heavy daily smoker (ORadj=2.54, 95% CI: 1.37–4.70) and less perceived addiction (not addicted: ORadj=3.26, 95% CI: 1.73–6.14; not much: ORadj= 1.95, 95% CI: 1.05–3.62 versus very much).
Conclusions: Mexican adult smokers who are non-daily smokers were more likely than daily heavy smokers to have attempted to quit during follow-up and to succeed in their quit attempt. Future research should determine whether tobacco control policies and programs potentiate this tendency and which interventions are needed to help heavier smokers to quit.
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Surani, et al. 2013. Intention to quit among Indian tobacco users: Findings from International Tobacco Control Policy Evaluation India Pilot Survey [show abstract ▼] [hide abstract ▲] [access full article]
Citation
Surani, N., Gupta, P.C., Fong, G.T., Pednekar, M.S., Quah, A.C.K., Bansal-Travers, M. (2012). Intention to quit among Indian tobacco users: Findings from International Tobacco Control Policy Evaluation India Pilot Survey. Indian Journal of Cancer, 49(4), 431-437.
Abstract
Introduction: Tobacco users face barriers not just in quitting, but also in thinking about quitting. The aim of this study was to understand factors encouraging intention to quit from the 2006 International Tobacco Control Policy (TCP) Evaluation India Pilot Study Survey.
Materials and Methods: A total of 764 adult respondents from urban and rural areas of Maharashtra and Bihar were surveyed through face-to-face individual interviews, with a house-to-house approach. Dependent variable was "intention to quit tobacco." Independent variables were demographic variables, peer influence, damage perception, receiving advice to quit, and referral to cessation services by healthcare professionals and exposure to anti-tobacco messages. Logistic regression model was used with odds ratio adjusted for location, age, gender, and marital status for statistical analysis.
Results: Of 493 tobacco users, 32.5% intended to quit. More numbers of users who were unaware about their friends' tobacco use intended to quit compared to those who were aware (adjusted OR = 8.06, 95% CI = 4.58-14.19). Higher numbers of users who felt tobacco has damaged their health intended to quit compared to those who did not feel that way (adjusted OR = 5.62, 95% CI = 3.53-8.96). More numbers of users exposed to anti-tobacco messages in newspapers/magazines (adjusted OR = 1.76, 95% CI = 1.02-3.03), restaurants (adjusted OR = 2.47, 95% CI = 1.37-4.46), radio (adjusted OR=4.84, 95% CI = 3.01-7.78), cinema halls (adjusted OR = 9.22, 95% CI = 5.31-15.75), and public transportation (adjusted OR = 10.58, 95% = 5.90-18.98) intended to quit compared to unexposed users.
Conclusion: Anti-tobacco messages have positive influence on user's intentions to quit.
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Yong, et al. 2013. Urban Chinese smokers from lower socioeconomic backgrounds face more barriers to quitting: Results from the International Tobacco Control China Survey [show abstract ▼] [hide abstract ▲]
Citation
Yong, H., Siahpush, M., Borland, R., Li, L., O’Connor, R.J., Yang, J., Fong, G.T., Jiang, Y. (2013). Urban Chinese smokers from lower socioeconomic backgrounds face more barriers to quitting: Results from the International Tobacco Control China Survey. Nicotine & Tobacco Research, 15(6), 1044-1051.
Abstract
Introduction: Research findings on social disparities in barriers to quitting faced by smokers from mainly Western English-language countries may or may not generalize to smokers in China. This paper sought to determine whether nicotine dependence, quitting self-efficacy, quitting interest differ by socio-economic status (SES), and whether they mediate the relationship between SES and quitting behavior of urban Chinese smokers.
Methods: Data come from 7,309 adult smokers who participated in the first 3 waves of the International Tobacco Control-China survey conducted in 7 cities across China. The association of socio-economic indicators with nicotine dependence, quitting self-efficacy, quitting interest, and behavior was evaluated using generalized estimating equations models along with a formal test of mediational effects.
Results: The SES index indicated that those from lower SES were significantly more addicted (p < .001), less confident (p < .001), and less interested in quitting (p < .05). This finding was replicated by education and employment status, but it was not clearly related to income. Mediational analyses revealed that the effects of SES on making quit attempts and quit success among those who tried were indirect. For quit attempts, self-efficacy, interest to quit, and heaviness of smoking index (HSI) were all significant mediators of the SES effect (p < .001), but for maintenance, only HSI was a significant mediator (p < .001).
Conclusions: Urban Chinese smokers from lower socio- economic backgrounds experience greater levels of psychological and behavioral barriers to quitting than their counterparts from higher socio-economic backgrounds and as such, they need more help to quit and do so successfully.
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Szklo, et al. 2013. Understanding the relationship between socioeconomic status, smoking cessation services provided by the health system and smoking cessation behaviour in Brazil [show abstract ▼] [hide abstract ▲]
Citation
Szklo, A.S., Thrasher, J.F., Perez-Hernandez, R., Figueiredo, V., Fong, G.T., de Almeida, L.M. (2013). Understanding the relationship between socioeconomic status, smoking cessation services provided by the health system and smoking cessation behavior in Brazil. Cadernos de Saude Publica, 29(3), 485-495.
Abstract
Increasing the effectiveness of smoking cessation policies requires greater consideration of the cultural and socioeconomic complexities of smoking. The purpose of this paper is to explore the association between socioeconomic status and “selected midpoints” linked to smoking cessation in Brazil. Data was collected from a representative sample of urban adult smokers as part of the ITC-Brazil Survey (2009, N = 1,215). After controlling for age and gender, there were no statistically significant differences quit attempts in the last six months between individuals with different socioeconomic status. However, smokers with high socioeconomic status visited a doctor 1.54 times more often than those with low socioeconomic status (p-value = 0.017), and were also 1.65 times more likely to receive advice to quit smoking (p-value = 0.025). Our results demonstrate that disparities in health and socioeconomic status are still a major challenge for policymakers to increase the population impact of tobacco control actions worldwide.
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Adkison, et al. 2013. Electronic nicotine delivery systems: International Tobacco Control Four-Country Survey [show abstract ▼] [hide abstract ▲]
Citation
Adkison, S., O’Connor, R.J., Bansal-Travers, M., Hyland, A., Borland, R., Yong, H.H., Cummings, K.M., McNeill, A., Thrasher, J.F., Hammond, D., Fong, G.T. (2013). Electronic nicotine delivery systems: International Tobacco Control Four-Country Survey. American Journal of Preventive Medicine, 44(3), 207-215.
Abstract
Background: Electronic nicotine delivery systems (ENDS) initially emerged in 2003 and have since become widely available globally, particularly over the Internet.
Purpose: Data on ENDS usage patterns are limited. The current paper examines patterns of ENDS awareness, use, and product-associated beliefs among current and former smokers in four countries.
Methods: Data come from Wave 8 of the International Tobacco Control Four-Country Survey, collected July 2010 to June 2011 and analyzed through June 2012. Respondents included 5939 current and former smokers in Canada (n_1581); the U.S. (n_1520); the United Kingdom (UK; n_1325); and Australia (n_1513).
Results: Overall, 46.6% were aware of ENDS (U.S.: 73%, UK: 54%, Canada: 40%, Australia: 20%); 7.6% had tried ENDS (16% of those aware of ENDS); and 2.9% were current users (39% of triers). Awareness of ENDS was higher among younger, non-minority smokers with higher incomes who were heavier smokers. Prevalence of trying ENDS was higher among younger, nondaily smokers with a high income and among those who perceived ENDS as less harmful than traditional cigarettes. Current use was higher among both nondaily and heavy (_20 cigarettes per day) smokers. In all, 79.8% reported using ENDS because they were considered less harmful than traditional cigarettes; 75.4% stated that they used ENDS to help them reduce their smoking; and 85.1% reported using ENDS to help them quit smoking.
Conclusions: Awareness of ENDS is high, especially in countries where they are legal (i.e., the U.S. and UK). Because trial was associated with nondaily smoking and a desire to quit smoking, ENDS may have the potential to serve as a cessation aid.
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Partos, et al. 2013. The quitting rollercoaster: How recent quitting history affects future cessation outcomes (data from the International Tobacco Control 4-Country Cohort Study) [show abstract ▼] [hide abstract ▲]
Citation
Partos, T.R., Borland, R., Yong, H.H., Hyland, A., Cummings, K.M. (2013). The quitting rollercoaster: How recent quitting history affects future cessation outcomes (data from the International Tobacco Control 4-Country Cohort Study). Nicotine & Tobacco Research, 15(9), 1578-1587.
Abstract
Introduction: Most smokers have a history of unsuccessful quit attempts. This study used data from 7 waves (2002–2009) of the International Tobacco Control 4-country cohort study to examine the role of smokers’ quitting history (e.g., recency, length, and number of previous quit attempts) on their subsequent likelihood of making a quit attempt and achieving at least 6 months of sustained abstinence.
Methods: Generalized estimating equations were used, allowing for estimation of relationships between variables across repeated observations while controlling for correlations from multiple responses by the same individual (29,682 observations from 13,417 individuals).
Results: The likelihood of a future quit attempt increased independently with recency and number of prior attempts. By contrast, the likelihood of achieving sustained abstinence of at least 6 months was reduced for smokers with a failed quit attempt within the last year (15.1% vs. 27.1% for those without, p < .001). Two or more failed attempts (vs. only one) in the previous year were also associated with a lower likelihood of achieving sustained abstinence (OR: 0.57, 95% CI: 0.38–0.85). Effects persisted after controlling for levels of addiction, self-efficacy to quit, and use of stop-smoking medications.
Conclusions: There appears to be a subset of smokers who repeatedly attempt but fail to remain abstinent from tobacco. Understanding why repeated attempts might be less successful in the long term is an important research priority because it implies a need to tailor treatment approaches for those who are motivated to quit but persistently relapse back to smoking.
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Sansone, et al. 2013. Comparing the experience of regret and its predictors among smoking adults in four countries [show abstract ▼] [hide abstract ▲] [access full article]
Citation
Sansone, N., Fong, G.T., Lee, W.B., Laux, F., Sirirassamee, B., Seo, H.G., Omar, M., Jiang, Y. (2013). Comparing the experience of regret and its predictors among smokers in four Asian countries: Findings from the ITC Surveys in Thailand, South Korea, Malaysia, and China. Nicotine & Tobacco Research, 15(10), 1663-1672.
Abstract
Introduction: Nearly all smokers in high-income Western countries report that they regret smoking (Fong, G. T., Hammond, D., Laux, F. L., Zanna, M. P., Cummings, M. K., Borland, R., & Ross, H. [2004]. The near-universal experience of regret among smokers in four countries: Findings from the International Tobacco Control Policy Evaluation Survey. Nicotine and Tobacco Research, 6, S341–S351. doi:10.1080/14622200412331320743), but no research to date has examined the prevalence of regret among smokers in non-Western, low- and middle-income countries.
Methods: Data were from the International Tobacco Control (ITC) Surveys of smokers in 4 Asian countries (China, Malaysia, South Korea, and Thailand); N = 9,738. Regret was measured with the statement: “If you had to do it over again, you would not have started smoking.”
Results: Prevalence of regret in 3 countries (South Korea = 87%, Malaysia = 77%, and China = 74%) was lower than that found by Fong et al. in the United States, Australia, Canada, and the United Kingdom (89%–90%); but was higher in Thailand (93%). These significant country differences in regret corresponded with differences in tobacco control and norms regarding smoking. The predictors of regret in the Asian countries were very similar to those in the 4 Western countries: Regret was more likely to be experienced by smokers who smoked fewer cigarettes per day, perceived greater benefits of quitting and higher financial costs of smoking, had more prior quit attempts, worried that smoking would damage their health, and felt that their loved ones and society disapproved of smoking. Regret was also positively associated with intentions to quit (r = 0.23, p < .001).
Conclusions: Across the Asian countries and high-income Western countries, the prevalence of regret varies, but the factors predicting regret are quite consistent. Regret may be an important indicator of tobacco control and is related to factors associated with future quitting.
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Sansone, et al. 2013. Time perspective as a predictor of smoking status: Findings from the International Tobacco Control (ITC) Surveys in Scotland, France, Germany, China, and Malaysia [show abstract ▼] [hide abstract ▲]
Citation
Sansone, G., Fong, G.T., Hall, P.A., Guignard, R., Beck, F., Mons, U., Pötschke-Langer, M., Yong, H.H., Thompson, M.E., Omar, M., Jiang, Y. (2013). Time perspective as a predictor of smoking status: Findings from the International Tobacco Control (ITC) Surveys in Scotland, France, Germany, China, and Malaysia. BioMed Central Public Health, 13(1), 346.
Abstract
Background: Prior studies have demonstrated that time perspective—the propensity to consider shortversus long-term consequences of one’s actions—is a potentially important predictor of health-related behaviors, including smoking. However, most prior studies have been conducted within single highincome countries. The aim of this study was to examine whether time perspective was associated with the likelihood of being a smoker or non-smoker across five countries that vary in smoking behavior and strength of tobacco control policies.
Methods: The data were from the International Tobacco Control (ITC) Surveys in five countries with large probability samples of both smokers (N=10,341) and non-smokers (N=4,955): Scotland, France, Germany, China, and Malaysia. The surveys were conducted between 2005 and 2008. Survey respondents indicated their smoking status (smoker vs. non-smoker) and time perspective (future oriented vs. not future-oriented) and provided demographic information.
Results: Across all five countries, non-smokers were significantly more likely to be future-oriented (66%) than were smokers (57%), χ2 (1, N = 15,244) = 120.64, p < .001. This bivariate relationship between time perspective and smoking status held in a multivariate analysis. After controlling for country, age, sex, income, education, and ethnicity (language in France), those who were future-oriented had 36% greater odds of being a non-smoker than a smoker (95% CI: 1.22 to 1.51, p<.001).
Conclusion: These findings establish time perspective as an important predictor of smoking status across multiple countries and suggest the potential value of incorporating material to enhance future orientation in smoking cessation interventions.
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Fong, et al. 2013. Évaluation de l’interdiction de fumer dans les lieux publics en France un an et cinq ans après sa mise en œuvre [show abstract ▼] [hide abstract ▲]
Citation
Fong, G.T., Craig, L., Guignard, R., Nagelhout, G.E., Tait, M., Driezen, P., Kennedy, R.D., Boudreau, C., Wilquin, J.L., Deutsch, A., Beck, F. (2013). Évaluation de l’interdiction de fumer dans les lieux publics en France un an et cinq ans après sa mise en œuvre: Résultats de l’enquête ITC France. Bulletin Epidémiologique Hebdomadaire, 20(21), 217-223.
Abstract
France implemented a comprehensive smoke-free policy in public places in February 2007 for workplaces, shopping centres, airports, train stations, hospitals and schools. On January 2008, it was extended to meeting places (bars, restaurants, hotels, casinos, nightclubs). This paper evaluates France’s smoke-free law based on the International Tobacco Control Policy Evaluation Project in France (the ITC France Project), which conducted a cohort survey of approximately 1,500 smokers and 500 non-smokers before the implementation of the laws (Wave 1, conducted December 2006 to February 2007) and two waves after the implementation (Wave 2, conducted between September-November 2008; and Wave 3, conducted between September-December 2012). Results show that the smoke-free law led to a very significant and near total elimination of indoor smoking in key venues such as bars (from 95.9% to 3.7%) and restaurants (from 64.7% to 2.3%) at Wave 2, which was sustained four years later at Wave 3 (1.4% in restaurants; 6.6% in bars). Smoking in workplaces declined significantly after the law (from 42.6% to 19.3%), which continued to decline at Wave 3 (to 12.8%). Support for the smoke-free law increased significantly after their implementation and continued to increase at Wave 3 (among smokers for bars and restaurants; among smokers and non-smokers for workplaces). The findings demonstrate that smoke-free policies that are implemented in ways consistent with the Guidelines for Article 8 of the WHO Framework Convention on Tobacco Control (WHO FCTC) lead to substantial and sustained reductions in tobacco smoke in public places while also leading to high levels of support by the public.
En France, l’interdiction de fumer dans les lieux publics a été mise en œuvre en février 2007 pour les lieux de travail, les centres commerciaux, les aéroports, les gares, les hôpitaux et les écoles. En janvier 2008, elle a été étendue aux lieux de convivialité (bars, restaurants, hôtels, casinos, discothèques). L’évaluation proposée dans cet article s’inscrit dans le cadre du volet français d’International Tobacco Control (ITC), projet d’évaluation des politiques publiques de lutte antitabac. Une enquête de cohorte d’environ 1 500 fumeurs et 500 non-fumeurs a été mise en place avant la mise en œuvre de la loi (vague 1, de décembre 2006 à février 2007); la vague 2 a eu lieu entre septembre et novembre 2008, et la vague 3, entre septembre et décembre 2012. Les résultats de la vague 2 montrent que la législation antitabac a conduit, dès la fin 2008, à une élimination quasi totale du tabagisme à l’intérieur d’endroits clés tels que les bars (de 95,9% à 3,7%) et les restaurants (de 64,7% à 2,3%), persistant quatre ans plus tard (1,4% dans les restaurants, 6,6% dans les bars à la vague 3). Le tabagisme sur le lieu de travail a diminué de façon significative après la loi (de 42,6% à 19,3%) et a continué de baisser (12,8%) à la vague 3. Le soutien à l’interdiction de fumer dans les lieux publics a augmenté de façon significative après sa mise en œuvre et a continué d’augmenter à la vague 3 (parmi les fumeurs concernant les bars et restaurants, parmi les fumeurs et les non-fumeurs concernant les lieux de travail). Les résultats démontrent que les politiques antitabac mises en œuvre de manière cohérente avec les lignes directrices relatives à l’article 8 de la Convention-cadre de l’OMS pour la lutte antitabac (CCLAT) conduisent à des réductions substantielles et durables du tabagisme passif dans les lieux publics, ainsi qu’à des niveaux de soutien élevés par la population.
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Adkison, et al. 2013. Impact of reduced ignition propensity cigarette regulation on consumer smoking behavior and quit intentions: Evidence from 6 waves (2004–11) of the ITC Four Country Survey [show abstract ▼] [hide abstract ▲]
Citation
Adkison, S., O’Connor, R.J., Borland, R., Yong, H.H., Cummings, K.M., Hammond, D., Fong, G.T. (2013). Impact of reduced ignition propensity cigarette regulation on consumer smoking behavior and quit intentions: Evidence from 6 waves (2004–11) of the ITC Four Country Survey. Tobacco Induced Diseases, 11(1), 26.
Abstract
Background: Although on the decline, smoking-related fires remain a leading cause of fire death in the United States and United Kingdom and account for over 10% of fire-related deaths worldwide. This has prompted lawmakers to enact legislation requiring manufacturers to implement reduced ignition propensity (RIP) safety standards for cigarettes. The current research evaluates how implementation of RIP safety standards in different countries influenced smokers’ perceptions of cigarette selfextinguishment, frequency of extinguishment, and the impact on consumer smoking behaviors, including cigarettes smoked per day and planning to quit.
Methods: Participants for this research come from Waves 3 through 8 of the International Tobacco Control (ITC) Four Country Survey conducted longitudinally from 2004 through 2011 in the United States, United Kingdom, Australia, and Canada.
Results: Perceptions of cigarette self-extinguishment and frequency of extinguishment increased concurrently with an increase in the prevalence of RIP safety standards for cigarettes. Presence of RIP safety standards was also associated with a greater intention to quit smoking, but was not associated with the number of cigarettes smoked per day. Intention to quit was higher among those who were more likely to report that their cigarettes self-extinguish sometimes and often, but we found no evidence of an interaction between frequency of extinguishment and RIP safety standards on quit intentions.
Conclusions: Overall, because these standards largely do not influence consumer smoking behavior, RIP implementation may significantly reduce the number of cigarette-related fires and the associated death and damages. Further research should assess how implementation of RIP safety standards has influenced smoking-related fire incidence, deaths, and other costs associated with smoking-related fires.
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Mutti, et al. 2013. The efficacy of cigarette warning labels on health beliefs in the United States and Mexico [show abstract ▼] [hide abstract ▲]
Citation
Mutti, S., Hammond, D., Reid, J., Thrasher, J.F. (2013). The efficacy of cigarette warning labels on health beliefs in the United States and Mexico. Journal of Health Communication, 18(10), 1180-1192.
Abstract
Concern over health risks is the most common motivation for quitting smoking. Health warnings on tobacco packages are among the most prominent interventions to convey the health risks of smoking. Face-to-face surveys were conducted in Mexico (n = 1,072), and a web-based survey was conducted in the US (n = 1,449) to examine the efficacy of health warning labels on health beliefs. Respondents were randomly assigned to view two sets of health warnings (each with one text-only warning and 5–6 pictorial warnings) for two different health effects. Respondents were asked whether they believed smoking caused 12 different health effects. Overall, the findings indicate high levels of health knowledge in both countries for some health effects, although significant knowledge gaps remained; for example, less than half of respondents agreed that smoking causes impotence and less than one third agreed that smoking causes gangrene. Mexican respondents endorsed a greater number of correct beliefs about the health effects of smoking than did the U.S. sample. In both countries, viewing related health warning labels increased beliefs about the health risks of smoking, particularly for less well-known health effects such as gangrene, impotence, and stroke.
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